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Integrative Cancer Therapies, Vol. 2, No. 2, 147-154 (2003)
DOI: 10.1177/1534735403002002007

Vitamin C in Alternative Cancer Treatment: Historical Background

Keith I. Block, MD

Mark N. Mead, MS

Ascorbic acid is the single-nutrient supplement most commonly used by cancer patients, although in most cases this takes place without the physician's knowledge or supervision. A comprehensive review of the literature is presented on the impact of ascorbic acid on cancer survival. Findings from 6 uncontrolled studies suggest that ascorbic acid may increase survival, whereas 2 controlled trials have yielded null results. The relative strengths and limitations of these studies are discussed. A turning point occurred with the release of the 2 controlled (null) studies, which influenced many physicians to turn away from nutrition in the care of cancer patients. Controversy about these trials still persists, however, in the alternative cancer community.

Key Words: vitamin C • cancer • alternative medicine • orthomolecular medicine • human studies


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