Integrative Cancer Therapies

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Singh, N. P.
Right arrow Articles by Panwar, V. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, N. P.
Right arrow Articles by Panwar, V. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Integrative Cancer Therapies, Vol. 5, No. 4, 391-394 (2006)
DOI: 10.1177/1534735406295311
© 2006 SAGE Publications

Case Report of a Pituitary Macroadenoma Treated With Artemether

Narendra P. Singh, MBBS, MS

Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195. narendra{at}u.washington.edu

Vijay Kumar Panwar, MBBS

Primary Health Center, Jaroda, Muzafarnagar (U.P.), India.

Introduction: This report describes the case of a male patient with pituitary macroadenoma treated with the artemisinin analog artemether. Patient and Methods: A 75 year-old male patient presented with vision, hearing, and locomotion-related problems. Artemether was administered orally to the patient over a period of 12 months. Results: Although the tumor remained consistent in size, CT scan shows a reduction in its density, and clinically, the related symptoms and signs resolved significantly as therapy progressed. Discussion: Overall, the artemether treatment was beneficial in improving the patient's quality of life. Artemether and other artemisinin analogs offer promise for cancer therapy.

Key Words: artemether • artemisinin • pituitary gland • microadenoma • cancer • apoptosis

References

  • Kreutzer J, Fahlbusch R. Diagnosis and treatment of pituitary tumors. Curr Opin Neurol. 2004;17:693-703.[CrossRef][Medline] [Order article via Infotrieve]
  • Johnson MD, Woodburn CJ, Vance ML. Quality of life in patients with a pituitary adenoma. Pituitary. 2003;6:81-87.[CrossRef][Medline] [Order article via Infotrieve]
  • Senovilla L, Nunez L, de Campos JM, et al. Multifunctional cells in human pituitary adenomas: implications for paradoxical secretion and tumorigenesis. J Clin Endocrinol Metab. 2004; 89:4545-4552.[Abstract/Free Full Text]
  • Yildiz F, Zorlu F, Erbas F, Atahan L. Radiotherapy in the management of giant pituitary adenomas. Radiother Oncol. 1999; 32:233-237.
  • Park P, Chandler WF, Barkan AL, et al. The role of radiation therapy after surgical resection of nonfunctional pituitary macroadenomas. Neurosurg. 2004;55:100-106.[CrossRef][Medline] [Order article via Infotrieve]
  • Dekkers OM, Pereira AM, Roelfsema F, et al. Observation alone after transsphenoidal surgery for non-functioning pituitary macroadenoma. J Clin Endocrinol Metab. 2006;91:1796-1801.[Abstract/Free Full Text]
  • Sassolas G, Trouillas J, Treluyer C, Perrin G. Management of nonfunctioning pituitary adenomas. Acta Endocrinol. 1993;129 (Suppl):21-26.
  • Zhang F, Gosser DK Jr, Meshnick SR. Hemin-catalyzed decomposition of artemisinin (qinghaosu). Biochem Pharmacol. 1992;43: 1805-1809.[CrossRef][Medline] [Order article via Infotrieve]
  • Lai H, Singh NP. Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin. Cancer Lett. 1995;91:41-46.[CrossRef][Medline] [Order article via Infotrieve]
  • Singh NP, Lai H. Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells. Life Sci. 2001;70:49-56.[CrossRef][Medline] [Order article via Infotrieve]
  • Peys E, Vandenkerckhove J, Van Hemel J, Sas B. Intermediate term toxicity of repeated orally administered doses of the anti malarial beta-artemether in dogs. Exp Toxicol Pathol. 2006;57: 299-304.[CrossRef][Medline] [Order article via Infotrieve]
  • Utzinger J, Xiao SH, N'Goran EK, Bergquist R, Tanner M. The potential of artemether for the control of schistosomiasis. Int J Parasitol. 2001;31:1549-1562.[CrossRef][Medline] [Order article via Infotrieve]
  • Utzinger J, N'Goran E, N'Dri A, Lengeler C, Shuhua X, Tanner M. Oral artemether for prevention of infection: randomised controlled trial. Lancet. 2000;355:1320-1325.[CrossRef][Medline] [Order article via Infotrieve]
  • Xiao S, Yang Y, You Q, et al. Potential long-term toxicity of repeated orally administered doses of artemether in rats. Am J Trop Med Hyg. 2002;66:30-34.[Abstract]
  • Murray RA, Maheshwari HG, Russell EJ, Bauman G. Pituitary hypoplasia in patients with a mutation in the growth hormone–releasing hormone receptor gene. Am J Neuroradiol. 2000;21:685-689.[Abstract/Free Full Text]
  • Moore JC, Lai H, Li JR, McDougall JA, Singh NP, Chou CK. Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat. Cancer Lett. 1995;98:83-87.[Medline] [Order article via Infotrieve]
  • Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR. The anti-malarial artesunate is also active against cancer. Int J Oncol. 2001;18:767-773.[Medline] [Order article via Infotrieve]
  • Singh NP, Verma KB. Case report of a laryngeal squamous cell carcinoma treated with artesunate. Arch Oncol. 2002;10: 279-280.[CrossRef]
  • Berger TG, Dieckmann D, Efferth T, et al. Artesunate in the treatment of metastatic uveal melanoma-first experiences. Oncol Rep. 2005;14:1599-1603.[Medline] [Order article via Infotrieve]
  • Singh NP, Lai H. Artemisinin induces apoptosis in human cancer cells. AntiCancer Res. 2004;24:2277-2280.[Medline] [Order article via Infotrieve]
  • Ezzat S, Asa SL, Couldwell WT, et al. The prevalence of pituitary adenomas: a systematic review. Cancer. 2004;101:613-619.[CrossRef][Medline] [Order article via Infotrieve]
  • Feldkamp J, Santen R, Harms E, Aulich A, Modder U, Scherbaum WA. Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas—results of a prospective study. Clin Endocrinol (Oxf). 1999;51:109-113.[CrossRef][Medline] [Order article via Infotrieve]
  • Arita K, Tominaga A, Sugiyama K, et al. Natural course of incidentally found nonfunctioning pituitary adenoma, with special reference to pituitary apoplexy during follow-up examination. J Neurosurg. 2006;104:884-891.[Medline] [Order article via Infotrieve]
  • Kabil MS, Ebv JB, Shahinian HK. Fully endoscopic endonasal vs. transseptal transsphenoidal pituitary surgery. Minim Invasive Neurosurg. 2005;48:348-354.[CrossRef][Medline] [Order article via Infotrieve]
  • Zaugg M, Adaman O, Pescia R, Landolt AM. External irradiation of macroinvasive pituitary adenomas with telecobalt: a retrospective study with long-term follow-up in patients irradiated with doses mostly of between 40-45 Gy. Int J Radiat Oncol Biol Phys. 1995;32:671-680.[CrossRef][Medline] [Order article via Infotrieve]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Singh, N. P.
Right arrow Articles by Panwar, V. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, N. P.
Right arrow Articles by Panwar, V. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?