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Sonodynamic and Photodynamic Therapy in Advanced Breast Carcinoma: A Report of 3 Cases

Chemistry and Environment College, Southern China Normal University, Guangzhou, People's Republic of China, wangxhgz{at}163.com, Science Group, Melbourne, Australia, Cancer Decisions, Inc, Lemont, PA, USA

Weimin Zhang

Chemistry and Environment College, Southern China Normal University, Guangzhou, People's Republic of China, Science Group, Melbourne, Australia, Cancer Decisions, Inc, Lemont, PA, USA

Zhiyong Xu

Chemistry and Environment College, Southern China Normal University, Guangzhou, People's Republic of China, Science Group, Melbourne, Australia, Cancer Decisions, Inc, Lemont, PA, USA

Yifan Luo

Doug Mitchell

Chemistry and Environment College, Southern China Normal University, Guangzhou, People's Republic of China, Science Group, Melbourne, Australia, Cancer Decisions, Inc, Lemont, PA, USA

Ralph W. Moss

Liu Hua Qiao Hospital, Guangzhou 510010, People's Republic of China

Photodynamic therapy (PDT) is an established therapeutic method, first approved by the FDA for certain kinds of cancer in 1998. There are also increasing data to show that a related procedure, sonodynamic therapy (SDT), is a promising new modality for cancer treatment. Here, the authors report clinical results in 3 advanced refractory breast cancer patients who were treated using a combination of sonodynamic and photodynamic therapy (SPDT), along with conventional therapies. All 3 patients had pathologically proven metastatic breast carcinoma. These widely disseminated carcinomas had ultimately failed to respond to conventional therapy. A new sensitizing agent, Sonoflora 1^TM (SF1) was administered sublingually; then, after a 24-hour delay, patients were treated with a combination of light and ultrasound. All patients had significant partial or complete responses. SPDT is a promising new therapeutic combination for the treatment of breast cancer.

Key Words: sonosensitizer • photosensitizer • sonodynamic therapy • photodynamic therapy • chlorophyll derivatives • breast cancer

Integrative Cancer Therapies, Vol. 8, No. 3, 283-287 (2009)
DOI: 10.1177/1534735409343693


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