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Inhibitive Effect of Artemether on Tumor Growth and Angiogenesis in the Rat C6 Orthotopic Brain Gliomas Model

Cancer Institute, The 3rd Affiliated Hospital of Kunming Medical College, Yunnan University, Kunming 650091, China, wuzhiping2004{at}yahoo.com.cn

Cheng-wei Gao, Phd

School of Chemistry Science and Technology, Kunming 650091, China

Yong-gui Wu, MD

Department of Base Medicine, Yunnan Chinese Traditional Medical College, Yunnan University, Kunming 650091, China

Qi-shun Zhu, Phd

School of Life Science, Yunnan University, Kunming 650091, China

Yan Chen, Phd

Cancer Institute, The 3rd Affiliated Hospital of Kunming Medical College, Yunnan University, Kunming 650091, China

Xin Liu, MD

Cancer Institute, The 3rd Affiliated Hospital of Kunming Medical College, Yunnan University, Kunming 650091, China

Chuen Liu, MD

Cancer Institute, The 3rd Affiliated Hospital of Kunming Medical College, Yunnan University, Kunming 650091, China

To explore the inhibitive effect of artemether on glioma growth and angiogenesis in brain tumor bearing SD rat. MTT assay was used to evaluate the inhibitory effect of artemether treatment on C6 glioma cells. Forty SD rats which were subcutaneous planted with SD rat C6 glioma cell to establish SD rat orthotopic glioma model were divided resourcefully into 5 groups. each group was 8 rats. Length-path (a mm) and short-path (b mm) of tumor each rat was measured. Tumor volume was calculated using the following formula: V (mm³) = a²b_/6. Microvessel density (MVD) in different therapy groups was significantly lower than that in normal saline control group and brain glioma volume in different therapy groups was significantly smaller than that in normal saline control group. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis.

Key Words: artemether • SD rat • C6 glioma cell line • brain glioma • animal model • angiogenesis

This version was published on March 1, 2009

Integrative Cancer Therapies, Vol. 8, No. 1, 88-92 (2009)
DOI: 10.1177/1534735408330714


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