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Integrative Cancer Therapies
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Amelioration of Radiation-induced Hematological and Biochemical Alterations by Alstonia scholaris (a Medicinal Plant) Extract

Uma Gupta, MSc

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India

Swafiya Jahan, MSc

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India

Ranu Chaudhary, MSc

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India

Pradeep Kumar Goyal, PhD

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India, pkgoyal2002{at}rediffmail.com

The radioprotective efficacy of a hydro-alcoholic extracted material from the bark of Alstonia scholaris (ASE) was studied in mice against radiation-induced hematological and biochemical alterations. Swiss albino mice were administered ASE (100 mg/kg body weight/d for 5 consecutive day) orally prior to whole-body gamma irradiation (7.5 Gy). Radiation exposure resulted in a significant decline (P < .001) in erythrocytes and hemoglobin until the third day, following a gradual recovery (ie, day 7), but these values did not reach normal values during the remainder of the animals' life span. Hematocrit percentage declined significantly (P < .001) until day 15. In contrast, ASE-pretreated irradiated animals had significantly higher erythrocyte, hematocrit, and hemoglobin values than the irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in gamma-irradiated mice, whereas this increase was considerably lower in ASE-pretreated animals. Pretreatment with ASE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated animals. This study showed that ASE protects against radiation-induced hematological and biochemical alterations in Swiss albino mice.

Key Words: Alstonia scholaris • gamma radiation • hematological constituents • radioprotection • lipid peroxidation • glutathione

Integrative Cancer Therapies, Vol. 7, No. 3, 155-161 (2008)
DOI: 10.1177/1534735408322850
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