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Integrative Cancer Therapies
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*Cancer Alternative Therapies
*Complementary and Alternative Medicine
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Reviews

A Critical Review of Complementary Therapies for Cancer-Related Fatigue

Amit Sood, MD, MSc

Baldwin 4th Floor, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905; sood.amit{at}mayo.edu

Debra L. Barton, RN, PhD

Brent A. Bauer, MD

Charles L. Loprinzi, MD

Mayo Clinic College of Medicine, Rochester, Minnesota

Purpose: To review the available literature on the use of complementary and alternative medicine (CAM) treatments for cancer-related fatigue with an aim to develop directions for future research. Methods: PubMed, EMBASE, CINAHL, PsycINFO, and SPORTDiscus were searched for relevant studies. Original clinical trials reporting on the use of CAM treatments for cancer-related fatigue were abstracted and critically reviewed. Results: CAM interventions tested for cancer-related fatigue include acupuncture, aromatherapy, adenosine triphosphate infusions, energy conservation and activity management, healing touch, hypnosis, lectinstandardized mistletoe extract, levocarnitine, massage, mindfulness-based stress reduction, polarity therapy, relaxation, sleep promotion, support group, and Tibetan yoga. Several of these interventions seem promising in initial studies. Conclusion: Currently, insufficient data exist to recommend any specific CAM modality for cancer-related fatigue. Therefore, potentially effective CAM interventions ready for further study in large, randomized clinical trials (eg, acupuncture, massage, levocarnitine, and the use of mistletoe) should be pursued. Other interventions should be tested in well-designed feasibility and phase II trials.

Key Words: cancer • fatigue • complementary medicine • alternative medicine • supportive care • palliative care • herbal products • mind-body medicine

Integrative Cancer Therapies, Vol. 6, No. 1, 8-13 (2007)
DOI: 10.1177/1534735406298143
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