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Integrative Cancer Therapies, Vol. 4, No. 1, 32-44 (2005)
DOI: 10.1177/1534735404273861

Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later

Michael J. González

University of Puerto Rico, Medical Sciences Campus, Graduate School of Public Health, Department Human Development, Nutrition Program, PO Box 365067, San Juan, PR 00936-5067 mgonzalez{at}rcm.upr.edu.

Jorge R. Miranda-Massari

School of Pharmacy, Department of Pharmacy Practice, University of Puerto Rico, San Juan.

Edna M. Mora

School of Medicine, Surgery Division, University of Puerto Rico, and Puerto Rico Cancer Center, San Juan, Puerto Rico.

Angelik Guzmán

RECNAC II Project, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Department of Human Development, Nutrition Program, San Juan, Puerto Rico.

Neil H. Riordan

Ai Dan Incorp, Tempe, Arizona.

Hugh D. Riordan

Joseph J. Casciari

James A. Jackson

Center for the Improvement of Human Functioning, Wichita, Kansas.

Angel Román-Franco

Department of Pathology, University of Puerto Rico, San Juan.

The effect of ascorbic acid on cancer has been a subject of great controversy. This is a follow-up review of the 1979 article by Cameron, Pauling, and Leibovitz published in Cancer Research. In this updated version, the authors address general aspects of ascorbic acid and cancer that have been presented before, while reviewing, analyzing, and updating new existing literature on the subject. In addition, they present and discuss their own mechanistic hypothesis on the effect of ascorbic acid on the cancer cell. The objective of this review is to provide an updated scientific basis for the use of ascorbic acid, especially intravenously as adjuvant treatment in pharmacological nutritional oncology.

Key Words: vitamin C • intravenous ascorbic acid • cancer • tumor growth • nontoxic chemotherapy • antioxidant • prooxidant


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