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Integrative Cancer Therapies, Vol. 2, No. 4, 358-364 (2003)
DOI: 10.1177/1534735403259066
© 2003 SAGE Publications

Ganoderma Lucidum(Reishi) in Cancer Treatment

Daniel Sliva, PhD

Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202.d-silva{at}clarian.org

The popular edible mushroom Ganoderma lucidum(Reishi) has been widely used for the general promotion of health and longevity in Asian countries. The dried powder of Ganoderma lucidumwas popular as a cancer chemotherapy agent in ancient China. The authors recently demonstrated thatGanoderma luciduminhibits constitutively active transcription factors nuclear factor kappa B (NF-.B) and AP-1, which resulted in the inhibition of expression of urokinasetype plasminogen activator (uPA) and its receptor uPAR.Ganoderma lucidumalso suppressed cell adhesion and cell migration of highly invasive breast and prostate cancer cells, suggesting its potency to reduce tumor invasiveness. Thus, Ganoderma lucidumclearly demonstrates anticancer activity in experiments with cancer cells and has possible therapeutic potential as a dietary supplement for an alternative therapy for breast and prostate cancer. However, because of the availability of Ganoderma lucidum from different sources, it is advisable to test its biologic activity.

Key Words: Ganoderma lucidum • Reishi • breast and prostate cancer • signaling pathways • AP-1 • NF- B • uPA • uPAR


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