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Integrative Cancer Therapies, Vol. 1, No. 3, 271-286 (2002)

PC-SPES: A Brief Overview

Geoffrey A. Cordell

University of Illinois at Chicago

PC-SPES is a botanically based dietary supplement that hasbeen used by men following prostate cancer treatment to reduceprostate-specific antigen levels. It is a complex matrixcomprising 8 herbs whose known chemistry and biology donot account for the observed clinical activity. Recent disclosureshave forced the product to be withdrawn from the market.Aspects of previous scientific research on the product,including clinical information, are reviewed, and some suggestionsare offered for the future scientific needs of thisproduct. Some thoughts are also offered on what the recallof PC-SPES means for the future scientific directions of thedietary supplement industry.

Key Words: prostate cancer • herbal medicine • adulteration • PC-SPES • dietary supplement


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