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Integrative Cancer Therapies, Vol. 1, No. 3, 229-237 (2002)

Mitochondrial Uptake of Sestamibi Distinguishes Between Normal, Inflammatory Breast Changes, Pre-Cancers, and Infiltrating Breast Cancer

Richard M. Fleming

Camelot Foundation

The evaluation of breast tissue using nuclear imaging is dependentupon the delivery and uptake of the isotope bybreast tissue. This is dependent upon blood flow to thebreast and functioning mitochondria. This 2-part study investigated(1) differences in uptake of sestamibi when bloodflow is enhanced (breast enhanced scintigraphy test[BEST]), and (2) differences in isotope uptake in normal(Nl) breast tissue, inflammatory changes in breast tissue(ICB), and breast cancer (CA). In the first part of the study,10 women were compared using both Miraluma and BESTimaging; in the second part, 195 people were studied usingBEST imaging only. The results were compared withhistopathologic specimens. Little difference was noted betweenMiraluma and BEST imaging in the first part. Womenwith ICB showed a statistically significant (P < .05) increasein isotope uptake using BEST imaging. This difference waseven more significant (P < .005) in women with CA. Duringthe second part of the study, BEST imaging demonstrated anexponential increase in tracer uptake. When maximal countactivity was compared, there was a statistically significant (P<.001) difference between Nl and ICB, between ICB andatypia (A), and between A and CA. BEST imaging demonstratedsignificant increases in isotope delivery when comparedwith Miraluma imaging. These differences alloweddifferentiation of breast tissue, including the detection ofearly changes in breast tissue.

Key Words: breast cancer • BEST imaging • mitochondria • early detection


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