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Integrative Cancer Therapies
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Can the Consumption of Tomatoes or Lycopene Reduce Cancer Risk?

Eun-Sun Hwang, PhD

Department of Human Nutrition, University of Illinois at Chicago

Phyllis E. Bowen, PhD, RD

Department of Human Nutrition, University of Illinois at Chicago, pbowen{at}uic.edu

Lycopene, a natural antioxidant found predominantly in to mato products, is attracting attention as a cancer prevention agent. Serum and dietary lycopene levels have been found to be inversely related to the incidence of several types of cancer, including prostate cancer. Although the antioxidant properties of lycopene are thought to be primarily responsible for its apparent beneficial effects, other mechanisms may also be involved. We outline the possible mechanisms of action of lycopene and review the current findings of in vitroand in vivo studies in cancer prevention and to some extent treatment. We examine the epidemiologic evidence regarding consumption of tomato and tomato products with the risk of cancer at various sites. Data suggest lycopene may account for or contribute to chemoprevention, but this hypothesis requires further study. Numerous other potentially beneficial compounds are present in tomatoes and complex interactions among multiple components may contribute to the anticancer properties of tomatoes.

Integrative Cancer Therapies, Vol. 1, No. 2, 121-132 (2002)
DOI: 10.1177/153473540200100203
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Home page
 Exp Biol MedHome page
H. L. Hantz, L. F. Young, and K. R. Martin
Physiologically Attainable Concentrations of Lycopene Induce Mitochondrial Apoptosis in LNCaP Human Prostate Cancer Cells
Exp Biol Med, March 1, 2005; 230(3): 171 - 179.
[Abstract] [Full Text] [PDF]